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KMID : 0811720030070000182
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Korean Journal of Physiology & Pharmacology
2003 Volume.7 No. 0 p.182 ~ p.0
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Single Bee Venom Stimulation Suppresses Thermal Hyperalgesic Behavior in Neuropathic Pain Model of Rats: The Role of Spinal Alpha 2-Adrenoceptor
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Roh Dae-Hyun
Kwon Young-Bae
Kim Hyun-Woo
Ham Tae-Won
Yoon Seo-Yeon
Kang Seuk-Yun
Yang Il-Suk
Han Ho-Jae
Lee Jang-Hern
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Abstract
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Our previous studies demonstrated that long-term treatment of bee venom (BV) significantly suppressed hyperalgesic and allodynic behaviors in chronic constriction injury induced neuropathic pain model of rats. In the present study, we investigated whether single BV treatment produced anti-hyperalgesic and anti-allodynic effects in neuropathic pain condition. Single BV injection (0.25 mg/kg, s.c.) was applied into ipsilateral Zusanli point at 2 weeks after neuropathic surgery. A salient anti-hyperalgesic effect to heat stimulus was observed from 5 to 45 minutes after BV injection, while this anti-hyperalgesic effect was not detected at 60 minutes after BV stimulation. However, single treatment of BV did not produce anti-allodynic effect to mechanical stimulus that was observed in the repetitive BV treatment group of the previous studies. In addition, we examined whether anti-hyperalgesic effect of single BV treatment was related to the activation of spinal alpha 2-adrenoceptor. Intrathecal pretreatment with idazoxan (40μg/ rat), a alpha 2-adrenoceptor antagonist, completely blocked the anti-hyperalgesic effect of single BV stimulation. These results suggest that single treatment of BV suppresses thermal hyperalgesic behavior under neuropathic condition and this anti-hyperalgesic effect of BV stimulation is associated with the activation of alpha 2-adrenoceptors in spinal cord.
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KEYWORD
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Neuropathic pain, Bee venom, Alpha2-adrenoceptor, Hyperalgesia, Allodynia
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